Human gene
PMEL premelanosome protein
2 disease groups in OMIA reach this gene, through the animal gene that Ensembl gives as its ortholog. The page shows the chain. It does not say whether an animal is a model of a human disease.
Animal diseases
By each group's best natural-model score, highest first. How the score works.
| OMIA group | Name | Species | Animal gene | Ortholog | The chain reached | Best score |
|---|---|---|---|---|---|---|
| 1544 | Hypotrichosis with coat-colour dilution (rat-tail syndrome) | domestic cattle | PMEL | one to one | Drug |
49.0
|
| 211 | Coat colour, merle | dog | PMEL | one to one | Animal disease only |
Target evidence
Each Open Targets association between this gene and a human disease that a disease group reached.
| Human disease | Mondo | Score | Evidence |
|---|---|---|---|
| oculocutaneous albinism type 2 | MONDO:0008746 | 0.06 | 2 |
Drugs
Each ChEMBL drug that acts on this gene.
| Drug | How | Latest stage |
|---|---|---|
| Tebentafusp | binding agent | Approved |
| Imc-Gp100 | cross-linking agent | Early phase 1 |
The drug data is ChEMBL's, under CC BY-SA 3.0, and came through Open Targets release 26.09.