Comparative

Human gene

BCR breakpoint cluster region

ENSG00000186716 on Ensembl

3 disease groups in OMIA reach this gene, through the animal gene that Ensembl gives as its ortholog. The page shows the chain. It does not say whether an animal is a model of a human disease.

Animal diseases

By each group's best natural-model score, highest first. How the score works.

OMIA group Name Species Animal gene Ortholog The chain reached Best score
1513 Leukaemia, chronic myelogenous dog BCR one to one Drug 85.8
for chronic myeloid leukemia
1513 Leukaemia, chronic myelogenous pig BCR one to one Drug 85.8
for chronic myeloid leukemia
1573 Leukaemia, chronic monocytic dog BCR one to one Drug 82.8
for chronic myeloid leukemia
2299 Leukaemia, chronic myelomonocytic dog BCR one to one Drug 56.7
for juvenile myelomonocytic leukemia

Target evidence

Each Open Targets association between this gene and a human disease that a disease group reached.

Human disease Mondo Score Evidence
chronic myeloid leukemia MONDO:0011996 0.82 8,089
juvenile myelomonocytic leukemia MONDO:0011908 0.08 17

Drugs

Each ChEMBL drug that acts on this gene.

Drug How Latest stage
Asciminib inhibitor Approved
Bosutinib inhibitor Approved
Dasatinib Anhydrous inhibitor Approved
Imatinib inhibitor Approved
Nilotinib inhibitor Approved
Ponatinib inhibitor Approved
Olverembatinib inhibitor Phase 3
Radotinib inhibitor Phase 3
Vodobatinib inhibitor Phase 2

The drug data is ChEMBL's, under CC BY-SA 3.0, and came through Open Targets release 26.09.