Human gene
MYH6 myosin-6
2 disease groups in OMIA reach this gene, through the animal gene that Ensembl gives as its ortholog. The page shows the chain. It does not say whether an animal is a model of a human disease.
Animal diseases
By each group's best natural-model score, highest first. How the score works.
| OMIA group | Name | Species | Animal gene | Ortholog | The chain reached | Best score |
|---|---|---|---|---|---|---|
| 2953 | Cardiomyopathy, hypertrophic, MYH6-related | pig | LOC100736765 | one to one | Drug |
33.3
|
| 2039 | Abortion (embryonic lethality), MYH6-related | domestic cattle | MYH6 | one to one | Animal disease only |
Target evidence
Each Open Targets association between this gene and a human disease that a disease group reached.
| Human disease | Mondo | Score | Evidence |
|---|---|---|---|
| dilated cardiomyopathy 1EE | MONDO:0013198 | 0.74 | 306 |
| hypertrophic cardiomyopathy 14 | MONDO:0013197 | 0.65 | 2,271 |
Drugs
Each ChEMBL drug that acts on this gene.
| Drug | How | Latest stage |
|---|---|---|
| Mavacamten | inhibitor | Approved |
| Omecamtiv Mecarbil | activator | Approved |
| Danicamtiv | activator | Phase 2/3 |
The drug data is ChEMBL's, under CC BY-SA 3.0, and came through Open Targets release 26.09.