Human gene

DMD dystrophin

ENSG00000198947 on Ensembl

4 disease groups in OMIA reach this gene, through the animal gene that Ensembl gives as its ortholog. The page shows the chain. It does not say whether an animal is a model of a human disease.

Animal diseases

By each group's best natural-model score, highest first. How the score works.

OMIA group	Name	Species	Animal gene	Ortholog	The chain reached	Best score
1888	Muscular dystrophy, Becker type	domestic cat	DMD	one to one	Drug	93.7 for Becker muscular dystrophy
1888	Muscular dystrophy, Becker type	pig	DMD	one to one	Drug	93.7 for Becker muscular dystrophy
1081	Muscular dystrophy, Duchenne type	dog	DMD	one to one	Drug	92.4 for Duchenne muscular dystrophy
1081	Muscular dystrophy, Duchenne type	domestic cat	DMD	one to one	Drug	92.4 for Duchenne muscular dystrophy
1081	Muscular dystrophy, Duchenne type	pig	DMD	one to one	Drug	92.4 for Duchenne muscular dystrophy
1081	Muscular dystrophy, Duchenne type	Rhesus monkey	DMD	one to one	Drug	92.4 for Duchenne muscular dystrophy
1685	Stress syndrome, DMD-related	pig	DMD	one to one	Drug	59.0 for dilated cardiomyopathy 3B
2308	Cardiomyopathy, X-linked dilated	rabbit	DMD	one to one	Drug	59.0 for dilated cardiomyopathy 3B

Target evidence

Each Open Targets association between this gene and a human disease that a disease group reached.

Human disease	Mondo	Score	Evidence
Duchenne muscular dystrophy	MONDO:0010679	0.87	15,916
Becker muscular dystrophy	MONDO:0010311	0.82	2,434
dilated cardiomyopathy 3B	MONDO:0010542	0.78	480

Drugs

Each ChEMBL drug that acts on this gene.

Drug	How	Latest stage
Casimersen	positive modulator	Approved
Delandistrogene Moxeparvovec	exogenous gene	Approved
Eteplirsen	positive modulator	Approved
Golodirsen	positive modulator	Approved
Viltolarsen	positive modulator	Approved
Drisapersen	positive modulator	Phase 3
Suvodirsen	positive modulator	Phase 2/3
Suvodirsen Sodium	positive modulator	Unknown

The drug data is ChEMBL's, under CC BY-SA 3.0, and came through Open Targets release 26.09.