Human gene
COL11A2 collagen, type XI, alpha 2
1 disease group in OMIA reaches this gene, through the animal gene that Ensembl gives as its ortholog. The page shows the chain. It does not say whether an animal is a model of a human disease.
Animal diseases
By each group's best natural-model score, highest first. How the score works.
| OMIA group | Name | Species | Animal gene | Ortholog | The chain reached | Best score |
|---|---|---|---|---|---|---|
| 1772 | Skeletal dysplasia 2, COL11A2-related | dog | COL11A2 | one to one | Drug |
59.6
|
Target evidence
Each Open Targets association between this gene and a human disease that a disease group reached.
| Human disease | Mondo | Score | Evidence |
|---|---|---|---|
| otospondylomegaepiphyseal dysplasia, autosomal dominant | MONDO:0008490 | 0.80 | 170 |
| otospondylomegaepiphyseal dysplasia, autosomal recessive | MONDO:0044206 | 0.78 | 230 |
| fibrochondrogenesis 2 | MONDO:0013795 | 0.71 | 210 |
Drugs
Each ChEMBL drug that acts on this gene.
| Drug | How | Latest stage |
|---|---|---|
| Collagenase Clostridium Histolyticum | hydrolytic enzyme | Approved |
| Ocriplasmin | hydrolytic enzyme | Approved |
The drug data is ChEMBL's, under CC BY-SA 3.0, and came through Open Targets release 26.09.