Human gene
MT-ND4L NADH dehydrogenase subunit 4L
1 disease group in OMIA reaches this gene, through the animal gene that Ensembl gives as its ortholog. The page shows the chain. It does not say whether an animal is a model of a human disease.
Animal diseases
By each group's best natural-model score, highest first. How the score works.
| OMIA group | Name | Species | Animal gene | Ortholog | The chain reached | Best score |
|---|---|---|---|---|---|---|
| 2557 | Leber hereditary optic neuropathy | domestic cattle | ND4L | one to one | Drug |
77.5
|
Target evidence
Each Open Targets association between this gene and a human disease that a disease group reached.
| Human disease | Mondo | Score | Evidence |
|---|---|---|---|
| Leber hereditary optic neuropathy | MONDO:0010788 | 0.67 | 18 |
Drugs
Each ChEMBL drug that acts on this gene.
| Drug | How | Latest stage |
|---|---|---|
| Metformin | inhibitor | Approved |
| Me-344 | inhibitor | Phase 1/2 |
| Nv-128 | inhibitor | Unknown |
The drug data is ChEMBL's, under CC BY-SA 3.0, and came through Open Targets release 26.09.