OMIA group 1777
Mammary tumour
The chain reaches the human disease hereditary breast carcinoma, which Mondo defines as: “Breast carcinoma that has developed in relatives of patients with history of breast carcinoma.”
The chain
From the animal disease to the drugs. The page shows what each step found and where the chain stopped. It does not say whether the animal is a model of a human disease.
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Animal disease
Reached
OMIA records it in 5 species entries marked as a defect.
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Human disease
Reached
1 Mondo disease.
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Human gene
Reached
1 human gene.
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Target evidence
Reached
1 Open Targets association, with a best score of 0.50.
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Drugs
Reached
34 ChEMBL drugs, 3 approved. None has been tested for this disease.
Natural-model score
How complete and how well supported the chain to each human disease is, out of 100, by stated rules. It does not say that the animal is a validated model of the human disease. How the score works.
54.9 out of 100
| Part | Computed from | Points |
|---|---|---|
| Target evidence | Open Targets score of 0.50 | 17.4 of 35 |
| Drugs | Drugs act on its genes, but no drug has been tested for this disease | 2.5 of 25 |
| Ortholog | One to one ortholog | 20.0 of 20 |
| Both routes | One route found this disease | 5.0 of 10 |
| Species | 5 naturally occurring species entries marked as a defect | 10.0 of 10 |
Species
The chain follows only the species entries that OMIA marks as a defect.
| Species | Scientific name | OMIA entry | A defect |
|---|---|---|---|
| chimpanzee | Pan troglodytes | OMIA:001777-9598 | Yes |
| dog | Canis lupus familiaris | OMIA:001777-9615 | Yes |
| domestic cat | Felis catus | OMIA:001777-9685 | Yes |
| domestic cattle | Bos taurus | OMIA:001777-9913 | Yes |
| tiger | Panthera tigris | OMIA:001777-9694 | Yes |
Genes
Each gene OMIA records for a species entry, and the human gene it reaches through Ensembl's orthologs.
| Species | Animal gene | Human gene | Ortholog |
|---|---|---|---|
| chimpanzee | No gene | OMIA records no gene for this species entry. | |
| dog | PIK3CA phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha NCBI Gene 488084 | PIK3CA Ensembl | one to one |
| domestic cat | No gene | OMIA records no gene for this species entry. | |
| domestic cattle | No gene | OMIA records no gene for this species entry. | |
| tiger | No gene | OMIA records no gene for this species entry. | |
Human diseases
Two routes lead from an OMIA group to a Mondo human disease: OMIA's own Mondo link, and the group's OMIM numbers through Mondo's cross-references.
- OMIA's own Mondo link: OMIA links the group to no Mondo disease.
- OMIA's OMIM numbers: found a disease.
| Mondo disease | Name | Found by |
|---|---|---|
| MONDO:0016419 | hereditary breast carcinoma Breast carcinoma that has developed in relatives of patients with history of breast carcinoma. | OMIA's OMIM numbers |
Target evidence
Each Open Targets association between one of the group's human genes and one of its human diseases, with its overall score and the score for each kind of evidence.
| Human gene | Human disease | Score | Evidence | Kinds of evidence |
|---|---|---|---|---|
| PIK3CA | hereditary breast carcinoma | 0.50 | 30 | Genetic association 0.81 Literature 0.12 Genetic literature 0.01 |
Drugs
Drugs act on PIK3CA, but none has been tested for this disease.
| Drug | Acts on | How | Latest stage | Tested for this disease |
|---|---|---|---|---|
| Alpelisib | PIK3CA | inhibitor | Approved | No |
| Copanlisib | PIK3CA | inhibitor | Approved | No |
| Inavolisib | PIK3CA | inhibitor | Approved | No |
| Buparlisib | PIK3CA | inhibitor | Phase 3 | No |
| Dactolisib | PIK3CA | inhibitor | Phase 3 | No |
| Gedatolisib | PIK3CA | inhibitor | Phase 3 | No |
| Taselisib | PIK3CA | inhibitor | Phase 3 | No |
| Paxalisib | PIK3CA | inhibitor | Phase 2/3 | No |
| Apitolisib | PIK3CA | inhibitor | Phase 2 | No |
| Fimepinostat | PIK3CA | inhibitor | Phase 2 | No |
| Pf-04691502 | PIK3CA | inhibitor | Phase 2 | No |
| Pictilisib | PIK3CA | inhibitor | Phase 2 | No |
| Pilaralisib | PIK3CA | inhibitor | Phase 2 | No |
| Samotolisib | PIK3CA | inhibitor | Phase 2 | No |
| Serabelisib | PIK3CA | inhibitor | Phase 2 | No |
| Sf-1126 | PIK3CA | inhibitor | Phase 2 | No |
| Sonolisib | PIK3CA | inhibitor | Phase 2 | No |
| Voxtalisib | PIK3CA | inhibitor | Phase 2 | No |
| Izorlisib | PIK3CA | inhibitor | Phase 1/2 | No |
| Azd-6482 | PIK3CA | inhibitor | Phase 1 | No |
| Bay-1082439 | PIK3CA | inhibitor | Phase 1 | No |
| Ds-7423 | PIK3CA | inhibitor | Phase 1 | No |
| Gsk-1059615 | PIK3CA | inhibitor | Phase 1 | No |
| Omipalisib | PIK3CA | inhibitor | Phase 1 | No |
| Panulisib | PIK3CA | inhibitor | Phase 1 | No |
| Pki-179 | PIK3CA | inhibitor | Phase 1 | No |
| Recilisib | PIK3CA | inhibitor | Phase 1 | No |
| Vs-5584 | PIK3CA | inhibitor | Phase 1 | No |
| Wx-037 | PIK3CA | inhibitor | Phase 1 | No |
| Zstk-474 | PIK3CA | inhibitor | Phase 1 | No |
| Bgt-226 Free Base | PIK3CA | inhibitor | Unknown | No |
| Puquitinib | PIK3CA | inhibitor | Unknown | No |
| Pwt-33579 | PIK3CA | inhibitor | Unknown | No |
| Pwt-33587 | PIK3CA | inhibitor | Unknown | No |
The drug data is ChEMBL's, under CC BY-SA 3.0, and came through Open Targets release 26.09.