Comparative

Human gene

PIK3CA phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha

ENSG00000121879 on Ensembl

1 disease group in OMIA reaches this gene, through the animal gene that Ensembl gives as its ortholog. The page shows the chain. It does not say whether an animal is a model of a human disease.

Animal diseases

By each group's best natural-model score, highest first. How the score works.

OMIA group Name Species Animal gene Ortholog The chain reached Best score
1777 Mammary tumour dog PIK3CA one to one Drug 54.9
for hereditary breast carcinoma

Target evidence

Each Open Targets association between this gene and a human disease that a disease group reached.

Human disease Mondo Score Evidence
hereditary breast carcinoma MONDO:0016419 0.50 30

Drugs

Each ChEMBL drug that acts on this gene.

Drug How Latest stage
Alpelisib inhibitor Approved
Copanlisib inhibitor Approved
Inavolisib inhibitor Approved
Buparlisib inhibitor Phase 3
Dactolisib inhibitor Phase 3
Gedatolisib inhibitor Phase 3
Taselisib inhibitor Phase 3
Paxalisib inhibitor Phase 2/3
Apitolisib inhibitor Phase 2
Fimepinostat inhibitor Phase 2
Pf-04691502 inhibitor Phase 2
Pictilisib inhibitor Phase 2
Pilaralisib inhibitor Phase 2
Samotolisib inhibitor Phase 2
Serabelisib inhibitor Phase 2
Sf-1126 inhibitor Phase 2
Sonolisib inhibitor Phase 2
Voxtalisib inhibitor Phase 2
Izorlisib inhibitor Phase 1/2
Azd-6482 inhibitor Phase 1
Bay-1082439 inhibitor Phase 1
Ds-7423 inhibitor Phase 1
Gsk-1059615 inhibitor Phase 1
Omipalisib inhibitor Phase 1
Panulisib inhibitor Phase 1
Pki-179 inhibitor Phase 1
Recilisib inhibitor Phase 1
Vs-5584 inhibitor Phase 1
Wx-037 inhibitor Phase 1
Zstk-474 inhibitor Phase 1
Bgt-226 Free Base inhibitor Unknown
Puquitinib inhibitor Unknown
Pwt-33579 inhibitor Unknown
Pwt-33587 inhibitor Unknown

The drug data is ChEMBL's, under CC BY-SA 3.0, and came through Open Targets release 26.09.