Comparative

OMIA group 2254

Glucocorticoid resistance

The chain

From the animal disease to the drugs. The page shows what each step found and where the chain stopped. It does not say whether the animal is a model of a human disease.

  1. Animal disease

    Reached

    OMIA records it in 1 species entry marked as a defect.

  2. Human disease

    Reached

    1 Mondo disease.

  3. Human gene

    Reached

    1 human gene.

  4. Target evidence

    Reached

    1 Open Targets association, with a best score of 0.81.

  5. Drugs

    Reached

    75 ChEMBL drugs, 56 approved. None has been tested for this disease.

Natural-model score

How complete and how well supported the chain to each human disease is, out of 100, by stated rules. It does not say that the animal is a validated model of the human disease. How the score works.

glucocorticoid resistance

64.8 out of 100

Part Computed from Points
Target evidence Open Targets score of 0.81 28.3 of 35
Drugs Drugs act on its genes, but no drug has been tested for this disease 2.5 of 25
Ortholog One to one ortholog 20.0 of 20
Both routes Both routes found this disease 10.0 of 10
Species 1 naturally occurring species entry marked as a defect 4.0 of 10

Species

The chain follows only the species entries that OMIA marks as a defect.

Species Scientific name OMIA entry A defect
dog Canis lupus familiaris OMIA:002254-9615 Yes

Genes

Each gene OMIA records for a species entry, and the human gene it reaches through Ensembl's orthologs.

Species Animal gene Human gene Ortholog
dog NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) NCBI Gene 478047 NR3C1 Ensembl one to one

Human diseases

Two routes lead from an OMIA group to a Mondo human disease: OMIA's own Mondo link, and the group's OMIM numbers through Mondo's cross-references.

Mondo disease Name Found by
MONDO:0014421 glucocorticoid resistance Both routes

Target evidence

Each Open Targets association between one of the group's human genes and one of its human diseases, with its overall score and the score for each kind of evidence.

Human gene Human disease Score Evidence Kinds of evidence
NR3C1 glucocorticoid resistance 0.81 309 Genetic association 0.92 Genetic literature 0.73 Animal model 0.50 Literature 0.29

Drugs

Drugs act on NR3C1, but none has been tested for this disease.

Drug Acts on How Latest stage Tested for this disease
Alclometasone Dipropionate NR3C1 agonist Approved No
Amcinonide NR3C1 agonist Approved No
Beclomethasone Dipropionate NR3C1 agonist Approved No
Betamethasone NR3C1 agonist Approved No
Betamethasone Acetate NR3C1 agonist Approved No
Betamethasone Benzoate NR3C1 agonist Approved No
Betamethasone Dipropionate NR3C1 agonist Approved No
Betamethasone Valerate NR3C1 agonist Approved No
Budesonide NR3C1 agonist Approved No
Ciclesonide NR3C1 agonist Approved No
Clobetasol Propionate NR3C1 agonist Approved No
Clocortolone Pivalate NR3C1 agonist Approved No
Cortisone Acetate NR3C1 agonist Approved No
Cyproterone Acetate NR3C1 antagonist Approved No
Deflazacort NR3C1 agonist Approved No
Desonide NR3C1 agonist Approved No
Desoximetasone NR3C1 agonist Approved No
Dexamethasone NR3C1 agonist Approved No
Dexamethasone Acetate NR3C1 agonist Approved No
Dexamethasone Phosphoric Acid NR3C1 agonist Approved No
Diflorasone Diacetate NR3C1 agonist Approved No
Difluprednate NR3C1 agonist Approved No
Flumethasone Pivalate NR3C1 agonist Approved No
Flunisolide NR3C1 agonist Approved No
Fluocinolone Acetonide NR3C1 agonist Approved No
Fluocinonide NR3C1 agonist Approved No
Fluorometholone NR3C1 agonist Approved No
Fluorometholone Acetate NR3C1 agonist Approved No
Fluprednisolone NR3C1 agonist Approved No
Flurandrenolide NR3C1 agonist Approved No
Fluticasone Furoate NR3C1 agonist Approved No
Fluticasone Propionate NR3C1 agonist Approved No
Halcinonide NR3C1 agonist Approved No
Halobetasol Propionate NR3C1 agonist Approved No
Hydrocortamate NR3C1 agonist Approved No
Hydrocortisone NR3C1 agonist Approved No
Hydrocortisone Acetate NR3C1 agonist Approved No
Hydrocortisone Butyrate NR3C1 agonist Approved No
Hydrocortisone Probutate NR3C1 agonist Approved No
Loteprednol Etabonate NR3C1 agonist Approved No
Medrysone NR3C1 agonist Approved No
Meprednisone NR3C1 agonist Approved No
Methylprednisolone NR3C1 agonist Approved No
Methylprednisolone Acetate NR3C1 agonist Approved No
Methylprednisolone Hemisuccinate NR3C1 agonist Approved No
Mifepristone NR3C1 antagonist Approved No
Mometasone Furoate NR3C1 agonist Approved No
Prednicarbate NR3C1 agonist Approved No
Prednisolone NR3C1 agonist Approved No
Prednisolone Acetate NR3C1 agonist Approved No
Prednisone NR3C1 agonist Approved No
Rimexolone NR3C1 agonist Approved No
Triamcinolone NR3C1 agonist Approved No
Triamcinolone Acetonide NR3C1 agonist Approved No
Triamcinolone Hexacetonide NR3C1 agonist Approved No
Vamorolone NR3C1 agonist Approved No
Mapracorat NR3C1 agonist Phase 3 No
Prednisolone Phosphoric Acid NR3C1 agonist Phase 3 No
Relacorilant NR3C1 antagonist Phase 3 No
Cortivazol NR3C1 agonist Phase 2/3 No
Abbv-3373 NR3C1 modulator Phase 2 No
Azd-5423 NR3C1 modulator Phase 2 No
Cort 108297 NR3C1 antagonist Phase 2 No
Fosdagrocorat NR3C1 modulator Phase 2 No
Org-34517 NR3C1 antagonist Phase 2 No
Velsecorat NR3C1 modulator Phase 2 No
Betamethasone Phosphoric Acid NR3C1 agonist Unknown No
Dagrocorat NR3C1 modulator Unknown No
Hydrocortisone Cypionate NR3C1 agonist Unknown No
Hydrocortisone Hemisuccinate Anhydrous NR3C1 agonist Unknown No
Hydrocortisone Phosphoric Acid NR3C1 agonist Unknown No
Hydrocortisone Valerate NR3C1 agonist Unknown No
Paramethasone Acetate NR3C1 agonist Unknown No
Prednisolone Tebutate NR3C1 agonist Unknown No
Triamcinolone Diacetate NR3C1 agonist Unknown No

The drug data is ChEMBL's, under CC BY-SA 3.0, and came through Open Targets release 26.09.