Comparative

Human gene

NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)

ENSG00000113580 on Ensembl

1 disease group in OMIA reaches this gene, through the animal gene that Ensembl gives as its ortholog. The page shows the chain. It does not say whether an animal is a model of a human disease.

Animal diseases

By each group's best natural-model score, highest first. How the score works.

OMIA group Name Species Animal gene Ortholog The chain reached Best score
2254 Glucocorticoid resistance dog NR3C1 one to one Drug 64.8
for glucocorticoid resistance

Target evidence

Each Open Targets association between this gene and a human disease that a disease group reached.

Human disease Mondo Score Evidence
glucocorticoid resistance MONDO:0014421 0.81 309

Drugs

Each ChEMBL drug that acts on this gene.

Drug How Latest stage
Alclometasone Dipropionate agonist Approved
Amcinonide agonist Approved
Beclomethasone Dipropionate agonist Approved
Betamethasone agonist Approved
Betamethasone Acetate agonist Approved
Betamethasone Benzoate agonist Approved
Betamethasone Dipropionate agonist Approved
Betamethasone Valerate agonist Approved
Budesonide agonist Approved
Ciclesonide agonist Approved
Clobetasol Propionate agonist Approved
Clocortolone Pivalate agonist Approved
Cortisone Acetate agonist Approved
Cyproterone Acetate antagonist Approved
Deflazacort agonist Approved
Desonide agonist Approved
Desoximetasone agonist Approved
Dexamethasone agonist Approved
Dexamethasone Acetate agonist Approved
Dexamethasone Phosphoric Acid agonist Approved
Diflorasone Diacetate agonist Approved
Difluprednate agonist Approved
Flumethasone Pivalate agonist Approved
Flunisolide agonist Approved
Fluocinolone Acetonide agonist Approved
Fluocinonide agonist Approved
Fluorometholone agonist Approved
Fluorometholone Acetate agonist Approved
Fluprednisolone agonist Approved
Flurandrenolide agonist Approved
Fluticasone Furoate agonist Approved
Fluticasone Propionate agonist Approved
Halcinonide agonist Approved
Halobetasol Propionate agonist Approved
Hydrocortamate agonist Approved
Hydrocortisone agonist Approved
Hydrocortisone Acetate agonist Approved
Hydrocortisone Butyrate agonist Approved
Hydrocortisone Probutate agonist Approved
Loteprednol Etabonate agonist Approved
Medrysone agonist Approved
Meprednisone agonist Approved
Methylprednisolone agonist Approved
Methylprednisolone Acetate agonist Approved
Methylprednisolone Hemisuccinate agonist Approved
Mifepristone antagonist Approved
Mometasone Furoate agonist Approved
Prednicarbate agonist Approved
Prednisolone agonist Approved
Prednisolone Acetate agonist Approved
Prednisone agonist Approved
Rimexolone agonist Approved
Triamcinolone agonist Approved
Triamcinolone Acetonide agonist Approved
Triamcinolone Hexacetonide agonist Approved
Vamorolone agonist Approved
Mapracorat agonist Phase 3
Prednisolone Phosphoric Acid agonist Phase 3
Relacorilant antagonist Phase 3
Cortivazol agonist Phase 2/3
Abbv-3373 modulator Phase 2
Azd-5423 modulator Phase 2
Cort 108297 antagonist Phase 2
Fosdagrocorat modulator Phase 2
Org-34517 antagonist Phase 2
Velsecorat modulator Phase 2
Betamethasone Phosphoric Acid agonist Unknown
Dagrocorat modulator Unknown
Hydrocortisone Cypionate agonist Unknown
Hydrocortisone Hemisuccinate Anhydrous agonist Unknown
Hydrocortisone Phosphoric Acid agonist Unknown
Hydrocortisone Valerate agonist Unknown
Paramethasone Acetate agonist Unknown
Prednisolone Tebutate agonist Unknown
Triamcinolone Diacetate agonist Unknown

The drug data is ChEMBL's, under CC BY-SA 3.0, and came through Open Targets release 26.09.