Comparative

OMIA group 2772

Frontotemporal dementia, MAPT-related

The chain reaches the human disease semantic dementia, which Mondo defines as: “Semantic dementia (SD) is a form of frontotemporal dementia (FTD), characterized by the progressive, amodal and profound loss of semantic knowledge (combination of visual associative agnosia, anomia, surface dyslexia or dysgraphia and disrupted comprehension of word meaning) and behavioral abnormalities, attributable to the degeneration of the anterior temporal lobes.”

The chain

From the animal disease to the drugs. The page shows what each step found and where the chain stopped. It does not say whether the animal is a model of a human disease.

  1. Animal disease

    Reached

    OMIA records it in 2 species entries marked as a defect.

  2. Human disease

    Reached

    1 Mondo disease.

  3. Human gene

    Reached

    1 human gene.

  4. Target evidence

    Reached

    1 Open Targets association, with a best score of 0.64.

  5. Drugs

    Reached

    6 ChEMBL drugs, 0 approved. None has been tested for this disease.

Natural-model score

How complete and how well supported the chain to each human disease is, out of 100, by stated rules. It does not say that the animal is a validated model of the human disease. How the score works.

semantic dementia

66.3 out of 100

Part Computed from Points
Target evidence Open Targets score of 0.64 22.3 of 35
Drugs A drug has reached phase 2 for this disease 15.0 of 25
Ortholog One to one ortholog 20.0 of 20
Both routes One route found this disease 5.0 of 10
Species 1 naturally occurring species entry marked as a defect. 1 genetically engineered entry is not counted 4.0 of 10

Species

The chain follows only the species entries that OMIA marks as a defect.

Species Scientific name OMIA entry A defect
crab-eating macaque Genetically engineered, not naturally occurring. Not counted in the score. Macaca fascicularis OMIA:002772-9541 Yes
Rhesus monkey Macaca mulatta OMIA:002772-9544 Yes

Genes

Each gene OMIA records for a species entry, and the human gene it reaches through Ensembl's orthologs.

Species Animal gene Human gene Ortholog
crab-eating macaque MAPT microtubule associated protein tau NCBI Gene 102119414 MAPT Ensembl one to one
Rhesus monkey MAPT microtubule associated protein tau NCBI Gene 574327 MAPT Ensembl one to one

Human diseases

Two routes lead from an OMIA group to a Mondo human disease: OMIA's own Mondo link, and the group's OMIM numbers through Mondo's cross-references.

Mondo disease Name Found by
MONDO:0010857 semantic dementia Semantic dementia (SD) is a form of frontotemporal dementia (FTD), characterized by the progressive, amodal and profound loss of semantic knowledge (combination of visual associative agnosia, anomia, surface dyslexia or dysgraphia and disrupted comprehension of word meaning) and behavioral abnormalities, attributable to the degeneration of the anterior temporal lobes. OMIA's OMIM numbers

Target evidence

Each Open Targets association between one of the group's human genes and one of its human diseases, with its overall score and the score for each kind of evidence.

Human gene Human disease Score Evidence Kinds of evidence
MAPT semantic dementia 0.64 69 Genetic literature 0.81 Animal model 0.69 Genetic association 0.19 Literature 0.17

Drugs

Drugs act on MAPT, but none has been tested for this disease.

Drug Acts on How Latest stage Tested for this disease
Bepranemab MAPT inhibitor Phase 2 No
Gosuranemab MAPT inhibitor Phase 2 No
Posdinemab MAPT inhibitor Phase 2 No
Semorinemab MAPT inhibitor Phase 2 No
Tilavonemab MAPT inhibitor Phase 2 No
Zagotenemab MAPT inhibitor Phase 2 No

The drug data is ChEMBL's, under CC BY-SA 3.0, and came through Open Targets release 26.09.