Human gene
MAPT microtubule associated protein tau
1 disease group in OMIA reaches this gene, through the animal gene that Ensembl gives as its ortholog. The page shows the chain. It does not say whether an animal is a model of a human disease.
Animal diseases
By each group's best natural-model score, highest first. How the score works.
| OMIA group | Name | Species | Animal gene | Ortholog | The chain reached | Best score |
|---|---|---|---|---|---|---|
| 2772 | Frontotemporal dementia, MAPT-related | crab-eating macaque | MAPT | one to one | Drug |
66.3
|
| 2772 | Frontotemporal dementia, MAPT-related | Rhesus monkey | MAPT | one to one | Drug |
66.3
|
Target evidence
Each Open Targets association between this gene and a human disease that a disease group reached.
| Human disease | Mondo | Score | Evidence |
|---|---|---|---|
| semantic dementia | MONDO:0010857 | 0.64 | 69 |
Drugs
Each ChEMBL drug that acts on this gene.
| Drug | How | Latest stage |
|---|---|---|
| Bepranemab | inhibitor | Phase 2 |
| Gosuranemab | inhibitor | Phase 2 |
| Posdinemab | inhibitor | Phase 2 |
| Semorinemab | inhibitor | Phase 2 |
| Tilavonemab | inhibitor | Phase 2 |
| Zagotenemab | inhibitor | Phase 2 |
The drug data is ChEMBL's, under CC BY-SA 3.0, and came through Open Targets release 26.09.