Comparative

OMIA group 944

Spongiform encephalopathy, susceptibility/resistance to

The chain reaches the human disease kuru, which Mondo defines as: “A prion disease found exclusively among the Fore linguistic group natives of the highlands of new guinea. The illness is primarily restricted to adult females and children of both sexes. It is marked by the subacute onset of tremor and ataxia followed by motor weakness and incontinence. Death occurs within 3-6 months of disease onset. The condition is associated with ritual cannibalism, and has become rare since this practice has been discontinued. Pathologic features include a noninflammatory loss of neurons that is most prominent in the cerebellum, glial proliferation, and amyloid plaques. (From Adams et al., Principles of Neurology, 6th ed, p773)” It reaches 1 more human disease, listed below.

The chain

From the animal disease to the drugs. The page shows what each step found and where the chain stopped. It does not say whether the animal is a model of a human disease.

  1. Animal disease

    Reached

    OMIA records it in 40 species entries marked as a defect.

  2. Human disease

    Reached

    2 Mondo diseases.

  3. Human gene

    Reached

    1 human gene.

  4. Target evidence

    Reached

    1 Open Targets association, with a best score of 0.39.

  5. Drugs

    Stopped here

    No ChEMBL drug acts on a human gene of the group's target evidence.

The chain stopped at Drugs: No ChEMBL drug acts on a human gene of the group's target evidence.

Natural-model score

How complete and how well supported the chain to each human disease is, out of 100, by stated rules. It does not say that the animal is a validated model of the human disease. How the score works.

kuru

48.7 out of 100

Part Computed from Points
Target evidence Open Targets score of 0.39 13.7 of 35
Drugs No drug has been tested for this disease, and none acts on its genes 0.0 of 25
Ortholog One to one ortholog 20.0 of 20
Both routes One route found this disease 5.0 of 10
Species 40 naturally occurring species entries marked as a defect 10.0 of 10
kuru, susceptibility to

35.0 out of 100

Part Computed from Points
Target evidence No Open Targets association with this disease 0.0 of 35
Drugs No drug has been tested for this disease, and none acts on its genes 0.0 of 25
Ortholog One to one ortholog 20.0 of 20
Both routes One route found this disease 5.0 of 10
Species 40 naturally occurring species entries marked as a defect 10.0 of 10

Species

The chain follows only the species entries that OMIA marks as a defect.

Species Scientific name OMIA entry A defect
American bison Bison bison OMIA:000944-9901 Yes
American mink Neogale vison OMIA:000944-452646 Unknown, not counted
Arabian camel Camelus dromedarius OMIA:000944-9838 Yes
Arabian oryx Oryx leucoryx OMIA:000944-39411 Yes
Bank vole Myodes glareolus OMIA:000944-447135 Yes
bighorn sheep Ovis canadensis OMIA:000944-37174 Yes
black-tailed deer Odocoileus hemionus columbianus OMIA:000944-9873 Unknown, not counted
blue antelope Hippotragus leucophaeus OMIA:000944-37185 Yes
Cervus elaphus hispanicus Cervus elaphus hispanicus OMIA:000944-141655 Yes
cheetah Acinonyx jubatus OMIA:000944-32536 Yes
chicken Gallus gallus OMIA:000944-9031 Yes
chital Axis axis OMIA:000944-30531 Unknown, not counted
common eland Tragelaphus oryx OMIA:000944-9945 Yes
coyote Canis latrans OMIA:000944-9614 Yes
crab-eating macaque Macaca fascicularis OMIA:000944-9541 Yes
deer Cervidae OMIA:000944-9850 Yes
dog Canis lupus familiaris OMIA:000944-9615 Yes
domestic cat Felis catus OMIA:000944-9685 Yes
domestic cattle Bos taurus OMIA:000944-9913 Yes
domestic ferret Mustela putorius furo OMIA:000944-9669 Unknown, not counted
domestic guinea pig Cavia porcellus OMIA:000944-10141 Unknown, not counted
domestic yak Bos grunniens OMIA:000944-30521 Yes
Eastern wapiti Cervus canadensis canadensis OMIA:000944-9861 Yes
Eurasian elk Alces alces OMIA:000944-9852 Yes
Eurasian tree sparrow Passer montanus OMIA:000944-9160 Yes
fallow deer Dama dama OMIA:000944-30532 Unknown, not counted
gemsbok Oryx gazella OMIA:000944-9958 Yes
goat Naturally occurring, and also genetically engineered. Capra hircus OMIA:000944-9925 Yes
golden hamster Mesocricetus auratus OMIA:000944-10036 Yes
greater kudu Tragelaphus strepsiceros OMIA:000944-9946 Yes
horse Equus caballus OMIA:000944-9796 Unknown, not counted
Japanese quail Coturnix japonica OMIA:000944-93934 Unknown, not counted
macaques Macaca OMIA:000944-9539 Unknown, not counted
mallard Anas platyrhynchos OMIA:000944-8839 Unknown, not counted
Manchurian Wapiti Cervus elaphus xanthopygus OMIA:000944-9865 Yes
mouflon Ovis aries musimon OMIA:000944-9938 Yes
mule deer Odocoileus hemionus OMIA:000944-9872 Yes
North American deer mouse Peromyscus maniculatus OMIA:000944-10042 Yes
nyala Tragelaphus angasii OMIA:000944-66437 Yes
pig Sus scrofa OMIA:000944-9823 Unknown, not counted
puma Puma concolor OMIA:000944-9696 Unknown, not counted
rabbit Oryctolagus cuniculus OMIA:000944-9986 Unknown, not counted
raccoon dog Nyctereutes procyonoides OMIA:000944-34880 Yes
red deer Cervus elaphus OMIA:000944-9860 Yes
Reeves' muntjac Muntiacus reevesi OMIA:000944-9886 Yes
reindeer Rangifer tarandus OMIA:000944-9870 Yes
Rhesus monkey Macaca mulatta OMIA:000944-9544 Unknown, not counted
ring-necked pheasant Phasianus colchicus OMIA:000944-9054 Unknown, not counted
Rupicapra pyrenaica pyrenaica Rupicapra pyrenaica pyrenaica OMIA:000944-130902 Yes
scimitar-horned oryx Oryx dammah OMIA:000944-59534 Yes
sheep Ovis aries OMIA:000944-9940 Yes
sika deer Cervus nippon OMIA:000944-9863 Yes
Spanish ibex Capra pyrenaica OMIA:000944-80419 Yes
water buffalo Bubalus bubalis OMIA:000944-89462 Unknown, not counted
Western roe deer Capreolus capreolus OMIA:000944-9858 Yes
white-tailed deer Odocoileus virginianus OMIA:000944-9874 Yes
white-tufted-ear marmoset Callithrix jacchus OMIA:000944-9483 Unknown, not counted
zebu cattle Bos indicus OMIA:000944-9915 Unknown, not counted

Genes

Each gene OMIA records for a species entry, and the human gene it reaches through Ensembl's orthologs.

Species Animal gene Human gene Ortholog
American bison No gene OMIA records no gene for this species entry.
Arabian camel No gene OMIA records no gene for this species entry.
Arabian oryx No gene OMIA records no gene for this species entry.
Bank vole PRNP NCBI Gene 125413743 Ensembl has no gene cross-references for this species.
bighorn sheep No gene OMIA records no gene for this species entry.
blue antelope No gene OMIA records no gene for this species entry.
Cervus elaphus hispanicus No gene OMIA records no gene for this species entry.
cheetah No gene OMIA records no gene for this species entry.
chicken Prnp prion protein NCBI Gene 24686 The gene belongs to a different species than the entry.
common eland No gene OMIA records no gene for this species entry.
coyote No gene OMIA records no gene for this species entry.
crab-eating macaque No gene OMIA records no gene for this species entry.
deer No gene OMIA records no gene for this species entry.
dog No gene OMIA records no gene for this species entry.
domestic cat No gene OMIA records no gene for this species entry.
domestic cattle PRNP prion protein NCBI Gene 281427 PRNP Ensembl one to one
domestic yak No gene OMIA records no gene for this species entry.
Eastern wapiti No gene OMIA records no gene for this species entry.
Eurasian elk No gene OMIA records no gene for this species entry.
Eurasian tree sparrow No gene OMIA records no gene for this species entry.
gemsbok No gene OMIA records no gene for this species entry.
goat PRNP prion protein NCBI Gene 102169975 PRNP Ensembl one to one
golden hamster No gene OMIA records no gene for this species entry.
greater kudu No gene OMIA records no gene for this species entry.
Manchurian Wapiti No gene OMIA records no gene for this species entry.
mouflon No gene OMIA records no gene for this species entry.
mule deer No gene OMIA records no gene for this species entry.
North American deer mouse No gene OMIA records no gene for this species entry.
nyala No gene OMIA records no gene for this species entry.
raccoon dog No gene OMIA records no gene for this species entry.
red deer No gene OMIA records no gene for this species entry.
Reeves' muntjac No gene OMIA records no gene for this species entry.
reindeer No gene OMIA records no gene for this species entry.
Rupicapra pyrenaica pyrenaica No gene OMIA records no gene for this species entry.
scimitar-horned oryx No gene OMIA records no gene for this species entry.
sheep PRNP prion protein NCBI Gene 493887 PRNP Ensembl one to one
sika deer No gene OMIA records no gene for this species entry.
Spanish ibex No gene OMIA records no gene for this species entry.
Western roe deer No gene OMIA records no gene for this species entry.
white-tailed deer PRNP NCBI Gene 110131178 Ensembl has no gene cross-references for this species.
American mink Not a defect, not counted No gene OMIA records no gene for this species entry.
black-tailed deer Not a defect, not counted No gene OMIA records no gene for this species entry.
chital Not a defect, not counted No gene OMIA records no gene for this species entry.
domestic ferret Not a defect, not counted No gene OMIA records no gene for this species entry.
domestic guinea pig Not a defect, not counted No gene OMIA records no gene for this species entry.
fallow deer Not a defect, not counted No gene OMIA records no gene for this species entry.
horse Not a defect, not counted No gene OMIA records no gene for this species entry.
Japanese quail Not a defect, not counted No gene OMIA records no gene for this species entry.
macaques Not a defect, not counted No gene OMIA records no gene for this species entry.
mallard Not a defect, not counted No gene OMIA records no gene for this species entry.
pig Not a defect, not counted No gene OMIA records no gene for this species entry.
puma Not a defect, not counted No gene OMIA records no gene for this species entry.
rabbit Not a defect, not counted No gene OMIA records no gene for this species entry.
Rhesus monkey Not a defect, not counted No gene OMIA records no gene for this species entry.
ring-necked pheasant Not a defect, not counted No gene OMIA records no gene for this species entry.
water buffalo Not a defect, not counted No gene OMIA records no gene for this species entry.
white-tufted-ear marmoset Not a defect, not counted No gene OMIA records no gene for this species entry.
zebu cattle Not a defect, not counted No gene OMIA records no gene for this species entry.

Human diseases

Two routes lead from an OMIA group to a Mondo human disease: OMIA's own Mondo link, and the group's OMIM numbers through Mondo's cross-references.

The two routes found different diseases.

Mondo disease Name Found by
MONDO:0006825 kuru A prion disease found exclusively among the Fore linguistic group natives of the highlands of new guinea. The illness is primarily restricted to adult females and children of both sexes. It is marked by the subacute onset of tremor and ataxia followed by motor weakness and incontinence. Death occurs within 3-6 months of disease onset. The condition is associated with ritual cannibalism, and has become rare since this practice has been discontinued. Pathologic features include a noninflammatory loss of neurons that is most prominent in the cerebellum, glial proliferation, and amyloid plaques. (From Adams et al., Principles of Neurology, 6th ed, p773) OMIA's own Mondo link
MONDO:0009500 kuru, susceptibility to OMIA's OMIM numbers

Target evidence

Each Open Targets association between one of the group's human genes and one of its human diseases, with its overall score and the score for each kind of evidence.

Human gene Human disease Score Evidence Kinds of evidence
PRNP kuru 0.39 51 Animal model 0.64 Genetic literature 0.61 Literature 0.10

Drugs

No ChEMBL drug acts on a human gene of the group's target evidence.