Human disease
type 1 diabetes mellitus
Mondo defines it as: “A chronic condition characterized by minimal or absent production of insulin by the pancreas.”
2 disease groups in OMIA reach this disease, through OMIA's own Mondo link or its OMIM numbers. The page shows the chain. It does not say whether an animal is a model of this disease.
Animal diseases
By natural-model score for this disease, highest first. The score says how complete and how well supported each chain is, by stated rules. How the score works.
| OMIA group | Name | Found by | Species | The chain reached | Score |
|---|---|---|---|---|---|
| 279 | Diabetes mellitus | OMIA's OMIM numbers | 11 | Target evidence |
65.7
|
| 283 | Diabetes mellitus, type 1 | Both routes | 5 | Human disease |
45.0
|
Human genes
Each human gene of these disease groups that Open Targets links to this disease.
| Human gene | Score | Evidence |
|---|---|---|
| INS | 0.73 | 29,547 |
Drugs tested for this disease
Each ChEMBL drug that has been tested for this disease, and the human genes above it acts on, if any. Open Targets gives some drugs, such as most enzyme replacement therapies, no target gene.
| Drug | Acts on | Latest stage for this disease |
|---|---|---|
| Dasiglucagon Hydrochloride | None of these genes | Approved |
| Donislecel | None of these genes | Approved |
| Empagliflozin | None of these genes | Approved |
| Insulin Detemir | None of these genes | Approved |
| Insulin Glargine | None of these genes | Approved |
| Sotagliflozin | None of these genes | Approved |
| Teplizumab | None of these genes | Approved |
| Carbamazepine | None of these genes | Awaiting approval |
| Acipimox | None of these genes | Phase 3 |
| Alemtuzumab | None of these genes | Phase 3 |
| Alirocumab | None of these genes | Phase 3 |
| Antilymphocyte Immunoglobulin (Horse) | None of these genes | Phase 3 |
| Atorvastatin | None of these genes | Phase 3 |
| Balaglitazone | None of these genes | Phase 3 |
| Baricitinib | None of these genes | Phase 3 |
| Basiliximab | None of these genes | Phase 3 |
| Begelomab | None of these genes | Phase 3 |
| Cadisegliatin | None of these genes | Phase 3 |
| Cholecalciferol | None of these genes | Phase 3 |
| Cyclosporine | None of these genes | Phase 3 |
| Daclizumab | None of these genes | Phase 3 |
| Dapagliflozin | None of these genes | Phase 3 |
| Dasiglucagon | None of these genes | Phase 3 |
| Dextrose | None of these genes | Phase 3 |
| Diapep-277 | None of these genes | Phase 3 |
| Dimethyl Fumarate | None of these genes | Phase 3 |
| Domperidone | None of these genes | Phase 3 |
| Ergocalciferol | None of these genes | Phase 3 |
| Etanercept | None of these genes | Phase 3 |
| Farglitazar | None of these genes | Phase 3 |
| Finerenone | None of these genes | Phase 3 |
| Glucagon | None of these genes | Phase 3 |
| Glutamate Decarboxylase 2 | None of these genes | Phase 3 |
| Glutamic Acid | None of these genes | Phase 3 |
| Icodextrin | None of these genes | Phase 3 |
| Insulin Aspart | None of these genes | Phase 3 |
| Insulin Degludec | None of these genes | Phase 3 |
| Insulin Efsitora Alfa | None of these genes | Phase 3 |
| Insulin Glulisine | None of these genes | Phase 3 |
| Insulin Human | None of these genes | Phase 3 |
| Insulin Human, Isophane | None of these genes | Phase 3 |
| Insulin Icodec | None of these genes | Phase 3 |
| Insulin, Isophane | None of these genes | Phase 3 |
| Insulin Lispro | None of these genes | Phase 3 |
| Insulin Peglispro | None of these genes | Phase 3 |
| Insulin Pork | None of these genes | Phase 3 |
| Insulin Susp Isophane Beef | None of these genes | Phase 3 |
| Ipragliflozin | None of these genes | Phase 3 |
| Itolizumab | None of these genes | Phase 3 |
| Ixmyelocel-T | None of these genes | Phase 3 |
| Lansoprazole | None of these genes | Phase 3 |
| Larazotide | None of these genes | Phase 3 |
| Liraglutide | None of these genes | Phase 3 |
| Metformin | None of these genes | Phase 3 |
| Metoclopramide | None of these genes | Phase 3 |
| Miglitol | None of these genes | Phase 3 |
| Naxifylline | None of these genes | Phase 3 |
| Omeprazole | None of these genes | Phase 3 |
| Otelixizumab | None of these genes | Phase 3 |
| Physioneal | None of these genes | Phase 3 |
| Pioglitazone | None of these genes | Phase 3 |
| Pramlintide | None of these genes | Phase 3 |
| Protamine Sulfate | None of these genes | Phase 3 |
| Pyridoxine | None of these genes | Phase 3 |
| Ragaglitazar | None of these genes | Phase 3 |
| Ramipril | None of these genes | Phase 3 |
| Reparixin | None of these genes | Phase 3 |
| Ruboxistaurin | None of these genes | Phase 3 |
| Saxagliptin Anhydrous | None of these genes | Phase 3 |
| Semaglutide | None of these genes | Phase 3 |
| Sirolimus | None of these genes | Phase 3 |
| Sitagliptin | None of these genes | Phase 3 |
| Tacrolimus Anhydrous | None of these genes | Phase 3 |
| Taspoglutide | None of these genes | Phase 3 |
| Telmisartan | None of these genes | Phase 3 |
| Tesaglitazar | None of these genes | Phase 3 |
| Thiamine Ion | None of these genes | Phase 3 |
| Tirzepatide | None of these genes | Phase 3 |
| Tresperimus | None of these genes | Phase 3 |
| Triptolide | None of these genes | Phase 3 |
| Verapamil | None of these genes | Phase 3 |
| Vildagliptin | None of these genes | Phase 3 |
| Vitamin B12 | None of these genes | Phase 3 |
| Vitamin B Complex | None of these genes | Phase 3 |
| Zimislecel | None of these genes | Phase 3 |
| Anakinra | None of these genes | Phase 2/3 |
| Bemiparin | None of these genes | Phase 2/3 |
| Cinnamon | None of these genes | Phase 2/3 |
| Exenatide | None of these genes | Phase 2/3 |
| Glyburide | None of these genes | Phase 2/3 |
| Omega-3 Fatty Acids | None of these genes | Phase 2/3 |
| Ustekinumab | None of these genes | Phase 2/3 |
| Abatacept | None of these genes | Phase 2 |
| Abrocitinib | None of these genes | Phase 2 |
| Acetazolamide | None of these genes | Phase 2 |
| Alagebrium | None of these genes | Phase 2 |
| Albiglutide | None of these genes | Phase 2 |
| Aldesleukin | None of these genes | Phase 2 |
| Alefacept | None of these genes | Phase 2 |
| .Alpha.1-Proteinase Inhibitor Human | None of these genes | Phase 2 |
| Aluminum Hydroxide | None of these genes | Phase 2 |
| Amitriptyline | None of these genes | Phase 2 |
| Aspirin | None of these genes | Phase 2 |
| Azd-1656 | None of these genes | Phase 2 |
| Azithromycin | None of these genes | Phase 2 |
| Bcg Live | None of these genes | Phase 2 |
| Bcg Vaccine | None of these genes | Phase 2 |
| Belatacept | None of these genes | Phase 2 |
| Brivekimig | None of these genes | Phase 2 |
| Bromocriptine | None of these genes | Phase 2 |
| Calcitriol | None of these genes | Phase 2 |
| Camicinal | None of these genes | Phase 2 |
| Canagliflozin Anhydrous | None of these genes | Phase 2 |
| Canakinumab | None of these genes | Phase 2 |
| Carvedilol | None of these genes | Phase 2 |
| Cbx-129801 | None of these genes | Phase 2 |
| Ccx354 | None of these genes | Phase 2 |
| Chlorthalidone | None of these genes | Phase 2 |
| Colchicine | None of these genes | Phase 2 |
| Dextran | None of these genes | Phase 2 |
| Dextran Sulfate Sodium | None of these genes | Phase 2 |
| Dextran Sulfate Sodium (5000 Mw) | None of these genes | Phase 2 |
| Dulaglutide | None of these genes | Phase 2 |
| Efalizumab | None of these genes | Phase 2 |
| Eflornithine | None of these genes | Phase 2 |
| Emapalumab | None of these genes | Phase 2 |
| Enoxaparin Sodium | None of these genes | Phase 2 |
| Estetrol Anhydrous | None of these genes | Phase 2 |
| Etrasimod | None of these genes | Phase 2 |
| Ezetimibe | None of these genes | Phase 2 |
| Fenofibrate | None of these genes | Phase 2 |
| Filgrastim | None of these genes | Phase 2 |
| Frexalimab | None of these genes | Phase 2 |
| Gamma-Aminobutyric Acid | None of these genes | Phase 2 |
| Ganciclovir | None of these genes | Phase 2 |
| Gastrin | None of these genes | Phase 2 |
| Gevokizumab | None of these genes | Phase 2 |
| Golimumab | None of these genes | Phase 2 |
| Hyaluronidase (Human Recombinant) | None of these genes | Phase 2 |
| Ibuprofen | None of these genes | Phase 2 |
| Icovamenib | None of these genes | Phase 2 |
| Imatinib | None of these genes | Phase 2 |
| Imcy-0098 | None of these genes | Phase 2 |
| Infliximab | None of these genes | Phase 2 |
| Interferon Alfa | None of these genes | Phase 2 |
| Iscalimab | None of these genes | Phase 2 |
| Ixekizumab | None of these genes | Phase 2 |
| Ladarixin | None of these genes | Phase 2 |
| Lenograstim | None of these genes | Phase 2 |
| Lisdexamfetamine | None of these genes | Phase 2 |
| Lisofylline | None of these genes | Phase 2 |
| Mbx-2982 | None of these genes | Phase 2 |
| Methyldopa | None of these genes | Phase 2 |
| Methylphenidate | None of these genes | Phase 2 |
| Mycophenolate Mofetil | None of these genes | Phase 2 |
| Nbi-6024 | None of these genes | Phase 2 |
| Ni-0801 | None of these genes | Phase 2 |
| Nnc0114-0006 | None of these genes | Phase 2 |
| Obexelimab | None of these genes | Phase 2 |
| Pancreatic Polypeptide | None of these genes | Phase 2 |
| Pantoprazole | None of these genes | Phase 2 |
| Pegfilgrastim | None of these genes | Phase 2 |
| Pg-102 | None of these genes | Phase 2 |
| Phenylalanine | None of these genes | Phase 2 |
| Pleconaril | None of these genes | Phase 2 |
| Remogliflozin Etabonate | None of these genes | Phase 2 |
| Rezpegaldesleukin | None of these genes | Phase 2 |
| Ribavirin | None of these genes | Phase 2 |
| Rilparencel | None of these genes | Phase 2 |
| Ritlecitinib | None of these genes | Phase 2 |
| Rituximab | None of these genes | Phase 2 |
| Secukinumab | None of these genes | Phase 2 |
| Semapimod | None of these genes | Phase 2 |
| Simvastatin | None of these genes | Phase 2 |
| Siplizumab | None of these genes | Phase 2 |
| Sorafenib | None of these genes | Phase 2 |
| Spergualin | None of these genes | Phase 2 |
| Tafasitamab | None of these genes | Phase 2 |
| Taurursodiol | None of these genes | Phase 2 |
| Tegoprubart | None of these genes | Phase 2 |
| Temelimab | None of these genes | Phase 2 |
| Tocilizumab | None of these genes | Phase 2 |
| Trofinetide | None of these genes | Phase 2 |
| Tzp-102 | None of these genes | Phase 2 |
| Ubidecarenone | None of these genes | Phase 2 |
| Ulodesine | None of these genes | Phase 2 |
| Vicasinabin | None of these genes | Phase 2 |
| Vobarilizumab | None of these genes | Phase 2 |
| Volagidemab | None of these genes | Phase 2 |
| Adalimumab | None of these genes | Phase 1/2 |
| Alprazolam | None of these genes | Phase 1/2 |
| Autologous Cord Blood | None of these genes | Phase 1/2 |
| Butyric Acid | None of these genes | Phase 1/2 |
| Cabiralizumab | None of these genes | Phase 1/2 |
| Cyclophosphamide Anhydrous | None of these genes | Phase 1/2 |
| Dantrolene | None of these genes | Phase 1/2 |
| Denosumab | None of these genes | Phase 1/2 |
| Emricasan | None of these genes | Phase 1/2 |
| Everolimus | None of these genes | Phase 1/2 |
| Foralumab | None of these genes | Phase 1/2 |
| Iohexol | None of these genes | Phase 1/2 |
| Oremepermin Alfa | None of these genes | Phase 1/2 |
| Plerixafor | None of these genes | Phase 1/2 |
| Recombinant Human Kallikrein-1 | None of these genes | Phase 1/2 |
| Rinvecalinase Alfa | None of these genes | Phase 1/2 |
| Taurine | None of these genes | Phase 1/2 |
| Adakitug | None of these genes | Phase 1 |
| Adomeglivant | None of these genes | Phase 1 |
| Afasevikumab | None of these genes | Phase 1 |
| Amp-110 | None of these genes | Phase 1 |
| Ascorbic Acid | None of these genes | Phase 1 |
| Atazanavir | None of these genes | Phase 1 |
| Bti-410 | None of these genes | Phase 1 |
| Chembl569766 | None of these genes | Phase 1 |
| Cusatuzumab | None of these genes | Phase 1 |
| Erythromycin | None of these genes | Phase 1 |
| Estradiol | None of these genes | Phase 1 |
| Fructose | None of these genes | Phase 1 |
| Gimsilumab | None of these genes | Phase 1 |
| Heparin | None of these genes | Phase 1 |
| Hyaluronidase | None of these genes | Phase 1 |
| Hydrocortisone | None of these genes | Phase 1 |
| Insulin Tregopil | None of these genes | Phase 1 |
| Lixisenatide | None of these genes | Phase 1 |
| Medroxyprogesterone Acetate | None of these genes | Phase 1 |
| Metreleptin | None of these genes | Phase 1 |
| Mk-2640 | None of these genes | Phase 1 |
| Moxifloxacin | None of these genes | Phase 1 |
| Nomacopan | None of these genes | Phase 1 |
| Ornithine | None of these genes | Phase 1 |
| Pamrevlumab | None of these genes | Phase 1 |
| Paridiprubart | None of these genes | Phase 1 |
| Perakizumab | None of these genes | Phase 1 |
| Pi-0824 | None of these genes | Phase 1 |
| Pitolisant | None of these genes | Phase 1 |
| Plx-5622 | None of these genes | Phase 1 |
| Ppi-2458 | None of these genes | Phase 1 |
| Rilonacept | None of these genes | Phase 1 |
| Sodium Chloride | None of these genes | Phase 1 |
| Somatostatin | None of these genes | Phase 1 |
| Somatropin | None of these genes | Phase 1 |
| Substance P | None of these genes | Phase 1 |
| Terbutaline | None of these genes | Phase 1 |
| Tgn-1412 | None of these genes | Phase 1 |
| Tifenazoxide | None of these genes | Phase 1 |
| Trx-1 | None of these genes | Phase 1 |
| Vorsetuzumab | None of these genes | Phase 1 |
| Zalfermin | None of these genes | Phase 1 |
| Dichloroacetic Acid | None of these genes | Early phase 1 |
| Fluoxetine | None of these genes | Early phase 1 |
| Glucagon-Like Peptide 1 | None of these genes | Early phase 1 |
| Pancreatin | None of these genes | Early phase 1 |
| Phentolamine | None of these genes | Early phase 1 |
| Propranolol | None of these genes | Early phase 1 |
| Resveratrol | None of these genes | Early phase 1 |
| Vedolizumab | None of these genes | Early phase 1 |
| Ac 710 | None of these genes | Investigational new drug |
| Cgi 1746 | None of these genes | Investigational new drug |
| Fluticasone | None of these genes | Investigational new drug |
| Fluticasone Propionate | None of these genes | Investigational new drug |
| Govorestat | None of these genes | Investigational new drug |
| Grc-15300 | None of these genes | Investigational new drug |
| Gsk-3050002 | None of these genes | Investigational new drug |
| Imlifidase | None of these genes | Investigational new drug |
| Platinum | None of these genes | Investigational new drug |
| Salmeterol | None of these genes | Investigational new drug |
| Selonsertib | None of these genes | Investigational new drug |
| Sodium Ferrous Citrate | None of these genes | Investigational new drug |
| Adenosine | None of these genes | Unknown |
| Alanine | None of these genes | Unknown |
| Avexitide | None of these genes | Unknown |
| Beta Carotene | None of these genes | Unknown |
| Candesartan | None of these genes | Unknown |
| Carnitine | None of these genes | Unknown |
| Clotrimazole | None of these genes | Unknown |
| Colesevelam | None of these genes | Unknown |
| Co-Trimoxazole | None of these genes | Unknown |
| Curcumin | None of these genes | Unknown |
| Darbepoetin Alfa | None of these genes | Unknown |
| Dexamethasone | None of these genes | Unknown |
| Diazoxide | None of these genes | Unknown |
| Enoxaparin | None of these genes | Unknown |
| Epinephrine | None of these genes | Unknown |
| Epoetin Alfa | None of these genes | Unknown |
| Epoetin Beta | None of these genes | Unknown |
| Fludrocortisone | None of these genes | Unknown |
| Formoterol | None of these genes | Unknown |
| Glutamine | None of these genes | Unknown |
| Levomefolic Acid | None of these genes | Unknown |
| Linagliptin | None of these genes | Unknown |
| Lipoic Acid, Alpha | None of these genes | Unknown |
| Mecasermin | None of these genes | Unknown |
| Mycophenolic Acid | None of these genes | Unknown |
| Oxytocin | None of these genes | Unknown |
| Pentoxifylline | None of these genes | Unknown |
| Selenium | None of these genes | Unknown |
| Spironolactone | None of these genes | Unknown |
| Trimethoprim | None of these genes | Unknown |
| Valganciclovir | None of these genes | Unknown |
| Vitamin E | None of these genes | Unknown |
| Zinc Acetate Anhydrous | None of these genes | Unknown |
| Zinc Sulfate | None of these genes | Unknown |
The drug data is ChEMBL's, under CC BY-SA 3.0, and came through Open Targets release 26.09.