Human disease
acquired polycythemia vera
Mondo defines it as: “An acquired myeloproliferative disorder characterized by an elevated absolute red blood cell mass caused by uncontrolled red blood cell production, frequently associated with uncontrolled white blood cell and platelet production.”
1 disease group in OMIA reaches this disease, through OMIA's own Mondo link or its OMIM numbers. The page shows the chain. It does not say whether an animal is a model of this disease.
Animal diseases
By natural-model score for this disease, highest first. The score says how complete and how well supported each chain is, by stated rules. How the score works.
| OMIA group | Name | Found by | Species | The chain reached | Score |
|---|---|---|---|---|---|
| 809 | Polycythemia | OMIA's OMIM numbers | 4 | Drug |
88.2
|
Human genes
Each human gene of these disease groups that Open Targets links to this disease.
| Human gene | Score | Evidence |
|---|---|---|
| JAK2 | 0.80 | 2,129 |
Drugs tested for this disease
Each ChEMBL drug that has been tested for this disease, and the human genes above it acts on, if any. Open Targets gives some drugs, such as most enzyme replacement therapies, no target gene.
| Drug | Acts on | Latest stage for this disease |
|---|---|---|
| Fedratinib | JAK2 | Approved |
| Momelotinib | JAK2 | Approved |
| Pacritinib | JAK2 | Approved |
| Peginterferon Alfa-2a | None of these genes | Approved |
| Ropeginterferon Alfa-2b | None of these genes | Approved |
| Ruxolitinib | JAK2 | Approved |
| Anagrelide | None of these genes | Phase 3 |
| Givinostat | None of these genes | Phase 3 |
| Hydroxyurea | None of these genes | Phase 3 |
| Interferon | None of these genes | Phase 3 |
| Interferon Alfa | None of these genes | Phase 3 |
| Interferon Alfa-2a | None of these genes | Phase 3 |
| Interferon Alfa-2b | None of these genes | Phase 3 |
| Novaferon | None of these genes | Phase 3 |
| Peginterferon Alfa-2b | None of these genes | Phase 3 |
| Pipobroman | None of these genes | Phase 3 |
| Rusfertide | None of these genes | Phase 3 |
| Sapablursen | None of these genes | Phase 3 |
| Navtemadlin | None of these genes | Phase 2/3 |
| Aspirin | None of these genes | Phase 2 |
| Bomedemstat | None of these genes | Phase 2 |
| Clopidogrel | None of these genes | Phase 2 |
| Cyclophosphamide Anhydrous | None of these genes | Phase 2 |
| Cyclosporine | None of these genes | Phase 2 |
| Dasatinib Anhydrous | None of these genes | Phase 2 |
| Doxorubicin | None of these genes | Phase 2 |
| Erlotinib | None of these genes | Phase 2 |
| Etoposide | None of these genes | Phase 2 |
| Fludarabine | None of these genes | Phase 2 |
| Gandotinib | JAK2 | Phase 2 |
| Idasanutlin | None of these genes | Phase 2 |
| Imatinib | None of these genes | Phase 2 |
| Imetelstat | None of these genes | Phase 2 |
| Lestaurtinib | JAK2 | Phase 2 |
| Luminespib | None of these genes | Phase 2 |
| Methotrexate | None of these genes | Phase 2 |
| Mirabegron | None of these genes | Phase 2 |
| Prednisone | None of these genes | Phase 2 |
| Rituximab | None of these genes | Phase 2 |
| Vincristine | None of these genes | Phase 2 |
| Zinpentraxin Alfa | None of these genes | Phase 2 |
| Acetylcysteine | None of these genes | Phase 1/2 |
| Pomalidomide | None of these genes | Phase 1/2 |
| Tasquinimod | None of these genes | Phase 1/2 |
| Umbralisib | None of these genes | Phase 1 |
| Xl-019 | JAK2 | Phase 1 |
| Xl019 | None of these genes | Phase 1 |
The drug data is ChEMBL's, under CC BY-SA 3.0, and came through Open Targets release 26.09.