Comparative

Human gene

F8 coagulation factor VIII

ENSG00000185010 on Ensembl

1 disease group in OMIA reaches this gene, through the animal gene that Ensembl gives as its ortholog. The page shows the chain. It does not say whether an animal is a model of a human disease.

Animal diseases

By each group's best natural-model score, highest first. How the score works.

OMIA group Name Species Animal gene Ortholog The chain reached Best score
437 Haemophilia A dog F8 one to one Drug 96.7
for hemophilia A
437 Haemophilia A domestic cat F8 one to one Drug 96.7
for hemophilia A
437 Haemophilia A domestic cattle F8 one to one Drug 96.7
for hemophilia A
437 Haemophilia A sheep F8 one to one Drug 96.7
for hemophilia A

Target evidence

Each Open Targets association between this gene and a human disease that a disease group reached.

Human disease Mondo Score Evidence
hemophilia A MONDO:0010602 0.91 5,181

Drugs

Each ChEMBL drug that acts on this gene.

Drug How Latest stage
Antihemophilic Factor, Pegylated (Mw 20000) Human Sequence Recombinant exogenous protein Approved
Damoctocog Alfa Pegol exogenous protein Approved
Drotrecogin Alfa (Activated) inhibitor Approved
Efanesoctocog Alfa exogenous protein Approved
Efmoroctocog Alfa exogenous protein Approved
Human Coagulation Factor Viii exogenous protein Approved
Lonoctocog Alfa exogenous protein Approved
Moroctocog Alfa exogenous protein Approved
Octocog Alfa exogenous protein Approved
Omfiloctocog Alfa exogenous protein Approved
Simoctocog Alfa exogenous protein Approved
Susoctocog Alfa exogenous protein Approved
Turoctocog Alfa exogenous protein Approved
Turoctocog Alfa Pegol exogenous protein Approved
Giroctocogene Fitelparvovec exogenous gene Phase 3
Tb-402 inhibitor Phase 2

The drug data is ChEMBL's, under CC BY-SA 3.0, and came through Open Targets release 26.09.