Comparative

OMIA group 437

Haemophilia A

The chain reaches the human disease hemophilia A, which Mondo defines as: “The most common form of hemophilia characterized by spontaneous or prolonged hemorrhages due to factor VIII deficiency.”

The chain

From the animal disease to the drugs. The page shows what each step found and where the chain stopped. It does not say whether the animal is a model of a human disease.

  1. Animal disease

    Reached

    OMIA records it in 7 species entries marked as a defect.

  2. Human disease

    Reached

    1 Mondo disease.

  3. Human gene

    Reached

    1 human gene.

  4. Target evidence

    Reached

    1 Open Targets association, with a best score of 0.91.

  5. Drugs

    Reached

    16 ChEMBL drugs, 14 approved. At least one has been tested for this disease.

Natural-model score

How complete and how well supported the chain to each human disease is, out of 100, by stated rules. It does not say that the animal is a validated model of the human disease. How the score works.

hemophilia A

96.7 out of 100

Part Computed from Points
Target evidence Open Targets score of 0.91 31.7 of 35
Drugs A drug has reached approved for this disease 25.0 of 25
Ortholog One to one ortholog 20.0 of 20
Both routes Both routes found this disease 10.0 of 10
Species 7 naturally occurring species entries marked as a defect 10.0 of 10

Species

The chain follows only the species entries that OMIA marks as a defect.

Species Scientific name OMIA entry A defect
crab-eating macaque Macaca fascicularis OMIA:000437-9541 Yes
dog Canis lupus familiaris OMIA:000437-9615 Yes
domestic cat Felis catus OMIA:000437-9685 Yes
domestic cattle Bos taurus OMIA:000437-9913 Yes
horse Equus caballus OMIA:000437-9796 Yes
pig Sus scrofa OMIA:000437-9823 Yes
sheep Ovis aries OMIA:000437-9940 Yes

Genes

Each gene OMIA records for a species entry, and the human gene it reaches through Ensembl's orthologs.

Species Animal gene Human gene Ortholog
crab-eating macaque No gene OMIA records no gene for this species entry.
dog F8 coagulation factor VIII, procoagulant component NCBI Gene 403875 F8 Ensembl one to one
domestic cat F8 coagulation factor VIII NCBI Gene 101092751 F8 Ensembl one to one
domestic cattle F8 coagulation factor VIII NCBI Gene 100271720 F8 Ensembl one to one
horse No gene OMIA records no gene for this species entry.
pig No gene OMIA records no gene for this species entry.
sheep F8 coagulation factor VIII, procoagulant component NCBI Gene 100359363 F8 Ensembl one to one

Human diseases

Two routes lead from an OMIA group to a Mondo human disease: OMIA's own Mondo link, and the group's OMIM numbers through Mondo's cross-references.

Mondo disease Name Found by
MONDO:0010602 hemophilia A The most common form of hemophilia characterized by spontaneous or prolonged hemorrhages due to factor VIII deficiency. Both routes

Target evidence

Each Open Targets association between one of the group's human genes and one of its human diseases, with its overall score and the score for each kind of evidence.

Human gene Human disease Score Evidence Kinds of evidence
F8 hemophilia A 0.91 5,181 Known drug 0.99 Genetic association 0.98 Literature 0.96 Affected pathway 0.93 Genetic literature 0.80

Drugs

A drug acts on F8 and has been tested for this disease.

Drug Acts on How Latest stage Tested for this disease
Antihemophilic Factor, Pegylated (Mw 20000) Human Sequence Recombinant F8 exogenous protein Approved Approved for hemophilia A
Damoctocog Alfa Pegol F8 exogenous protein Approved Approved for hemophilia A
Efanesoctocog Alfa F8 exogenous protein Approved Approved for hemophilia A
Efmoroctocog Alfa F8 exogenous protein Approved Approved for hemophilia A
Lonoctocog Alfa F8 exogenous protein Approved Approved for hemophilia A
Moroctocog Alfa F8 exogenous protein Approved Approved for hemophilia A
Octocog Alfa F8 exogenous protein Approved Approved for hemophilia A
Simoctocog Alfa F8 exogenous protein Approved Approved for hemophilia A
Susoctocog Alfa F8 exogenous protein Approved Approved for hemophilia A
Turoctocog Alfa F8 exogenous protein Approved Approved for hemophilia A
Turoctocog Alfa Pegol F8 exogenous protein Approved Approved for hemophilia A
Human Coagulation Factor Viii F8 exogenous protein Approved Phase 3 for hemophilia A
Omfiloctocog Alfa F8 exogenous protein Approved Phase 3 for hemophilia A
Giroctocogene Fitelparvovec F8 exogenous gene Phase 3 Phase 3 for hemophilia A
Drotrecogin Alfa (Activated) F8 inhibitor Approved No
Tb-402 F8 inhibitor Phase 2 No

The drug data is ChEMBL's, under CC BY-SA 3.0, and came through Open Targets release 26.09.