Human disease
hemophilia A
Mondo defines it as: “The most common form of hemophilia characterized by spontaneous or prolonged hemorrhages due to factor VIII deficiency.”
1 disease group in OMIA reaches this disease, through OMIA's own Mondo link or its OMIM numbers. The page shows the chain. It does not say whether an animal is a model of this disease.
Animal diseases
By natural-model score for this disease, highest first. The score says how complete and how well supported each chain is, by stated rules. How the score works.
| OMIA group | Name | Found by | Species | The chain reached | Score |
|---|---|---|---|---|---|
| 437 | Haemophilia A | Both routes | 7 | Drug |
96.7
|
Human genes
Each human gene of these disease groups that Open Targets links to this disease.
| Human gene | Score | Evidence |
|---|---|---|
| F8 | 0.91 | 5,181 |
Drugs tested for this disease
Each ChEMBL drug that has been tested for this disease, and the human genes above it acts on, if any. Open Targets gives some drugs, such as most enzyme replacement therapies, no target gene.
| Drug | Acts on | Latest stage for this disease |
|---|---|---|
| Antihemophilic Factor, Pegylated (Mw 20000) Human Sequence Recombinant | F8 | Approved |
| Concizumab | None of these genes | Approved |
| Damoctocog Alfa Pegol | F8 | Approved |
| Efanesoctocog Alfa | F8 | Approved |
| Efmoroctocog Alfa | F8 | Approved |
| Emicizumab | None of these genes | Approved |
| Eptacog Alfa (Activated) | None of these genes | Approved |
| Eptacog Beta (Activated) | None of these genes | Approved |
| Lonoctocog Alfa | F8 | Approved |
| Marstacimab | None of these genes | Approved |
| Moroctocog Alfa | F8 | Approved |
| Octocog Alfa | F8 | Approved |
| Simoctocog Alfa | F8 | Approved |
| Susoctocog Alfa | F8 | Approved |
| Tranexamic Acid | None of these genes | Approved |
| Turoctocog Alfa | F8 | Approved |
| Turoctocog Alfa Pegol | F8 | Approved |
| Valoctocogene Roxaparvovec | None of these genes | Approved |
| Anti-Inhibitor Coagulant Complex | None of these genes | Phase 3 |
| Bemiltenase Alfa | None of these genes | Phase 3 |
| Coagulation Factor Ix Recombinant Human | None of these genes | Phase 3 |
| Denecimig | None of these genes | Phase 3 |
| Eftrenonacog Alfa | None of these genes | Phase 3 |
| Fitusiran | None of these genes | Phase 3 |
| Giroctocogene Fitelparvovec | F8 | Phase 3 |
| Human Coagulation Factor Viii | F8 | Phase 3 |
| Marzeptacog Alfa (Activated) | None of these genes | Phase 3 |
| Omfiloctocog Alfa | F8 | Phase 3 |
| Von Willebrand Factor Human | None of these genes | Phase 3 |
| Ataluren | None of these genes | Phase 2 |
| Bay-1093884 | None of these genes | Phase 2 |
| Interferon Alfa-2a | None of these genes | Phase 2 |
| Oprelvekin | None of these genes | Phase 2 |
| Peginterferon Alfa-2a | None of these genes | Phase 2 |
| Peginterferon Alfa-2b | None of these genes | Phase 2 |
| Polyethylene Glycol | None of these genes | Phase 2 |
| Polyethylene Glycol 3350 | None of these genes | Phase 2 |
| Polyethylene Glycol 4000 | None of these genes | Phase 2 |
| Rituximab | None of these genes | Phase 2 |
| Rondaptivon Pegol | None of these genes | Phase 2 |
| Dirloctocogene Samoparvovec | None of these genes | Phase 1/2 |
| Desmopressin | None of these genes | Unknown |
The drug data is ChEMBL's, under CC BY-SA 3.0, and came through Open Targets release 26.09.