Comparative

Human disease

hepatocellular carcinoma

MONDO:0007256

Mondo defines it as: “A malignant tumor that arises from hepatocytes. Hepatocellular carcinoma is relatively rare in the United States but very common in all African countries south of the Sahara and in Southeast Asia. Most cases are seen in patients over the age of 50 years, but this tumor can also occur in younger individuals and even in children. Hepatocellular carcinoma is more common in males than females and is associated with hepatitis B, hepatitis C, chronic alcohol abuse and cirrhosis. Serum elevation of alpha-fetoprotein occurs in a large percentage of patients with hepatocellular carcinoma. Grossly, hepatocellular carcinoma may present as a single mass, as multiple nodules, or as diffuse liver involvement. Microscopically, there is a wide range of differentiation from tumor to tumor (well differentiated to poorly differentiated tumors). Hepatocellular carcinomas quickly metastasize to regional lymph nodes and lung. The overall median survival of untreated liver cell carcinoma is about 4 months. The most effective treatment of hepatocellular carcinoma is complete resection of the tumor. Lately, an increasing number of tumors have been treated with liver transplantation.”

1 disease group in OMIA reaches this disease, through OMIA's own Mondo link or its OMIM numbers. The page shows the chain. It does not say whether an animal is a model of this disease.

Animal diseases

By natural-model score for this disease, highest first. The score says how complete and how well supported each chain is, by stated rules. How the score works.

OMIA group Name Found by Species The chain reached Score
1990 Cancer, TP53-related OMIA's OMIM numbers 5 Drug 84.9

Human genes

Each human gene of these disease groups that Open Targets links to this disease.

Human gene Score Evidence
TP53 0.80 6,833
KRAS 0.51 498

Drugs tested for this disease

Each ChEMBL drug that has been tested for this disease, and the human genes above it acts on, if any. Open Targets gives some drugs, such as most enzyme replacement therapies, no target gene.

Drug Acts on Latest stage for this disease
Alcohol None of these genes Approved
Cabozantinib None of these genes Approved
Durvalumab None of these genes Approved
Fluorouracil None of these genes Approved
Leucovorin None of these genes Approved
Oxaliplatin None of these genes Approved
Sorafenib None of these genes Approved
Tremelimumab None of these genes Approved
Acetazolamide None of these genes Phase 3
Adebrelimab None of these genes Phase 3
Aglatimagene Besadenovec None of these genes Phase 3
Albumin Human None of these genes Phase 3
Arginine Hydrochloride None of these genes Phase 3
Atezolizumab None of these genes Phase 3
Benmelstobart None of these genes Phase 3
Bevacizumab None of these genes Phase 3
Brivanib None of these genes Phase 3
Brivanib Alaninate None of these genes Phase 3
Cadonilimab None of these genes Phase 3
Camrelizumab None of these genes Phase 3
Capecitabine None of these genes Phase 3
Carboplatin None of these genes Phase 3
Catequentinib None of these genes Phase 3
Chlorotrianisene None of these genes Phase 3
Cisplatin None of these genes Phase 3
Cs-1003 None of these genes Phase 3
Cyclophosphamide Anhydrous None of these genes Phase 3
Daclatasvir None of these genes Phase 3
Dasabuvir None of these genes Phase 3
Dexamethasone None of these genes Phase 3
Doxorubicin None of these genes Phase 3
Doxribtimine None of these genes Phase 3
Entecavir Anhydrous None of these genes Phase 3
Epirubicin None of these genes Phase 3
Erlotinib None of these genes Phase 3
Ethiodized Oil None of these genes Phase 3
Etoposide None of these genes Phase 3
Everolimus None of these genes Phase 3
Fexapotide None of these genes Phase 3
Gemcitabine None of these genes Phase 3
Gilvetmab None of these genes Phase 3
Hydroxycamptothecin None of these genes Phase 3
Icaritin None of these genes Phase 3
Interferon Alfa-2b None of these genes Phase 3
Iodine None of these genes Phase 3
Ipilimumab None of these genes Phase 3
Irinotecan None of these genes Phase 3
Ledipasvir None of these genes Phase 3
Lenvatinib None of these genes Phase 3
Levamisole None of these genes Phase 3
Levoleucovorin None of these genes Phase 3
Linifanib None of these genes Phase 3
Lobaplatin None of these genes Phase 3
Megestrol Acetate None of these genes Phase 3
Mitomycin None of these genes Phase 3
Muparfostat None of these genes Phase 3
Namodenoson None of these genes Phase 3
Nivolumab None of these genes Phase 3
Nolatrexed None of these genes Phase 3
Octreotide None of these genes Phase 3
Ombitasvir None of these genes Phase 3
Orantinib None of these genes Phase 3
Paritaprevir None of these genes Phase 3
Pegargiminase None of these genes Phase 3
Peginterferon Alfa-2b None of these genes Phase 3
Pembrolizumab None of these genes Phase 3
Penpulimab None of these genes Phase 3
Peretinoin None of these genes Phase 3
Pexastimogene Devacirepvec None of these genes Phase 3
Pirarubicin None of these genes Phase 3
Pravastatin None of these genes Phase 3
Ramucirumab None of these genes Phase 3
Regorafenib None of these genes Phase 3
Ribavirin None of these genes Phase 3
Rilvegostomig None of these genes Phase 3
Ritonavir None of these genes Phase 3
Rivoceranib None of these genes Phase 3
Seocalcitol None of these genes Phase 3
Serplulimab None of these genes Phase 3
Simeprevir None of these genes Phase 3
Sintilimab None of these genes Phase 3
Siponimod None of these genes Phase 3
Sirolimus None of these genes Phase 3
Sitravatinib None of these genes Phase 3
Sofosbuvir None of these genes Phase 3
Sunitinib None of these genes Phase 3
Talaporfin None of these genes Phase 3
Tamoxifen None of these genes Phase 3
Tenofovir Anhydrous None of these genes Phase 3
Tenofovir Disoproxil None of these genes Phase 3
Thalidomide None of these genes Phase 3
Tiragolumab None of these genes Phase 3
Tislelizumab None of these genes Phase 3
Tivantinib None of these genes Phase 3
Toripalimab None of these genes Phase 3
Trimetazidine None of these genes Phase 3
Vincristine None of these genes Phase 3
Yttrium None of these genes Phase 3
Zinc Acexamate None of these genes Phase 3
Arsenic Trioxide None of these genes Phase 2/3
Avelumab None of these genes Phase 2/3
Batabulin None of these genes Phase 2/3
Budigalimab None of these genes Phase 2/3
Cantharides Tincture None of these genes Phase 2/3
Finotonlimab None of these genes Phase 2/3
Idarubicin None of these genes Phase 2/3
Lanreotide None of these genes Phase 2/3
Livmoniplimab None of these genes Phase 2/3
Memantine None of these genes Phase 2/3
Nadroparin Calcium None of these genes Phase 2/3
Nicardipine None of these genes Phase 2/3
Tacrolimus Anhydrous None of these genes Phase 2/3
Tirapazamine None of these genes Phase 2/3
2-Mercaptoethanesulfonic Acid None of these genes Phase 2
Abc-294640 None of these genes Phase 2
Abemaciclib None of these genes Phase 2
Adagloxad Simolenin None of these genes Phase 2
Adakitug None of these genes Phase 2
Adefovir None of these genes Phase 2
Aldesleukin None of these genes Phase 2
Alvocidib None of these genes Phase 2
Amcasertib None of these genes Phase 2
Amino Acids None of these genes Phase 2
Amivantamab None of these genes Phase 2
Amsilarotene None of these genes Phase 2
Antilymphocyte Immunoglobulin (Horse) None of these genes Phase 2
Antimony None of these genes Phase 2
Apl-501 None of these genes Phase 2
Ascrinvacumab None of these genes Phase 2
Aspirin None of these genes Phase 2
Atorvastatin None of these genes Phase 2
Axitinib None of these genes Phase 2
Baclofen None of these genes Phase 2
Bavituximab None of these genes Phase 2
Becotatug Vedotin None of these genes Phase 2
Belzutifan None of these genes Phase 2
Bms-813160 None of these genes Phase 2
Bortezomib None of these genes Phase 2
Cabiralizumab None of these genes Phase 2
Cannabidiol None of these genes Phase 2
Capmatinib None of these genes Phase 2
Carotuximab None of these genes Phase 2
Carvedilol None of these genes Phase 2
Casdozokitug None of these genes Phase 2
Cediranib None of these genes Phase 2
Celecoxib None of these genes Phase 2
Cemiplimab None of these genes Phase 2
Ceritinib None of these genes Phase 2
Cetuximab None of these genes Phase 2
Cixutumumab None of these genes Phase 2
Clemizole None of these genes Phase 2
Cobolimab None of these genes Phase 2
Codrituzumab None of these genes Phase 2
Colchicine None of these genes Phase 2
Cyclosporine None of these genes Phase 2
Dalpiciclib None of these genes Phase 2
Danburstotug None of these genes Phase 2
Darinaparsin None of these genes Phase 2
Dasatinib Anhydrous None of these genes Phase 2
Denosumab None of these genes Phase 2
Docetaxel Anhydrous None of these genes Phase 2
Domvanalimab None of these genes Phase 2
Dostarlimab None of these genes Phase 2
Dovitinib None of these genes Phase 2
Dronabinol None of these genes Phase 2
Elbasvir None of these genes Phase 2
Endostatin None of these genes Phase 2
Endostatin, N-Terminal-Mggshhhhh None of these genes Phase 2
Enfortumab Vedotin None of these genes Phase 2
Envafolimab None of these genes Phase 2
Enzalutamide None of these genes Phase 2
Epalrestat None of these genes Phase 2
Epinephrine None of these genes Phase 2
Erfonrilimab None of these genes Phase 2
Etodolac None of these genes Phase 2
Exatecan None of these genes Phase 2
Ezurpimtrostat None of these genes Phase 2
Fianlimab None of these genes Phase 2
Filgrastim None of these genes Phase 2
Floxuridine None of these genes Phase 2
Fludarabine None of these genes Phase 2
Foslinanib None of these genes Phase 2
Fostamatinib None of these genes Phase 2
Fruquintinib None of these genes Phase 2
Futibatinib None of these genes Phase 2
Galunisertib None of these genes Phase 2
Gefitinib None of these genes Phase 2
Gimeracil None of these genes Phase 2
Grazoprevir Anhydrous None of these genes Phase 2
Guadecitabine None of these genes Phase 2
Hiltonol None of these genes Phase 2
Hydroxychloroquine None of these genes Phase 2
Icariin None of these genes Phase 2
Imatinib None of these genes Phase 2
Interferon None of these genes Phase 2
Interferon Alfa None of these genes Phase 2
Interferon Alfa-2a None of these genes Phase 2
Irpagratinib None of these genes Phase 2
Ispinesib None of these genes Phase 2
Ivarmacitinib None of these genes Phase 2
Ivonescimab None of these genes Phase 2
Lapatinib None of these genes Phase 2
Lenalidomide None of these genes Phase 2
Linsitinib None of these genes Phase 2
Melphalan None of these genes Phase 2
Metformin None of these genes Phase 2
Methotrexate None of these genes Phase 2
Milciclib None of these genes Phase 2
Mipsagargin None of these genes Phase 2
Mitoxantrone None of these genes Phase 2
Mk-2206 None of these genes Phase 2
Mycophenolate Mofetil None of these genes Phase 2
Nabiximols None of these genes Phase 2
Nimotuzumab None of these genes Phase 2
Nintedanib None of these genes Phase 2
Obi-3424 None of these genes Phase 2
Oblimersen Sodium None of these genes Phase 2
Ociperlimab None of these genes Phase 2
Onatasertib None of these genes Phase 2
Paclitaxel None of these genes Phase 2
Paclitaxel Docosahexaenoic Acid None of these genes Phase 2
Palbociclib None of these genes Phase 2
Pasireotide None of these genes Phase 2
Patupilone None of these genes Phase 2
Pegenzileukin None of these genes Phase 2
Peginterferon Alfa-2a None of these genes Phase 2
Perflutren None of these genes Phase 2
Pimurutamab None of these genes Phase 2
Platinum None of these genes Phase 2
Prednisone None of these genes Phase 2
Propranolol None of these genes Phase 2
P-Toluenesulfonamide None of these genes Phase 2
Pucotenlimab None of these genes Phase 2
Pyrazoloacridine None of these genes Phase 2
Pyrotinib None of these genes Phase 2
Quavonlimab None of these genes Phase 2
Raltitrexed None of these genes Phase 2
Refametinib None of these genes Phase 2
Relatlimab None of these genes Phase 2
Resminostat None of these genes Phase 2
Ribociclib None of these genes Phase 2
Rituximab None of these genes Phase 2
Rosiglitazone None of these genes Phase 2
S1? None of these genes Phase 2
Selgantolimod None of these genes Phase 2
Selumetinib None of these genes Phase 2
Sonidegib None of these genes Phase 2
Surufatinib None of these genes Phase 2
Suvemcitug None of these genes Phase 2
T-900607 None of these genes Phase 2
Tadalafil None of these genes Phase 2
Tasquinimod None of these genes Phase 2
Taurursodiol None of these genes Phase 2
Tazemetostat None of these genes Phase 2
Tegafur None of these genes Phase 2
Telatinib None of these genes Phase 2
Temozolomide None of these genes Phase 2
Temsirolimus None of these genes Phase 2
Tepotinib None of these genes Phase 2
Tertomotide None of these genes Phase 2
Thymalfasin None of these genes Phase 2
Tigatuzumab None of these genes Phase 2
Tinengotinib None of these genes Phase 2
Tiomolibdate Diammonium None of these genes Phase 2
Tivozanib None of these genes Phase 2
Tlc-388 None of these genes Phase 2
Tomivosertib None of these genes Phase 2
Trastuzumab None of these genes Phase 2
Trebananib None of these genes Phase 2
Tretazicar None of these genes Phase 2
Troculeucel None of these genes Phase 2
Tyrosine None of these genes Phase 2
Vancomycin None of these genes Phase 2
Vandetanib None of these genes Phase 2
Veliparib None of these genes Phase 2
Vipivotide Tetraxetan None of these genes Phase 2
Visugromab None of these genes Phase 2
Volrustomig None of these genes Phase 2
Yh-001 None of these genes Phase 2
Zabadinostat None of these genes Phase 2
Zanzalintinib None of these genes Phase 2
Zimberelimab None of these genes Phase 2
Zinc Sulfate None of these genes Phase 2
Zoledronic Acid Anhydrous None of these genes Phase 2
Abx-196 None of these genes Phase 1/2
Aeg-35156 None of these genes Phase 1/2
Aldoxorubicin None of these genes Phase 1/2
Allantoin None of these genes Phase 1/2
Ascorbic Acid None of these genes Phase 1/2
Avadomide None of these genes Phase 1/2
Bafisontamab None of these genes Phase 1/2
Belinostat None of these genes Phase 1/2
Bumetanide None of these genes Phase 1/2
C-188-9 None of these genes Phase 1/2
Cv-8102 None of these genes Phase 1/2
Cyc-065 None of these genes Phase 1/2
Dalantercept None of these genes Phase 1/2
Decitabine None of these genes Phase 1/2
Denileukin Diftitox None of these genes Phase 1/2
Dkn-01 None of these genes Phase 1/2
E-7386 None of these genes Phase 1/2
Eniluracil None of these genes Phase 1/2
Enlonstobart None of these genes Phase 1/2
Erdafitinib None of these genes Phase 1/2
Fgf401 None of these genes Phase 1/2
Fisogatinib None of these genes Phase 1/2
Folinic Acid None of these genes Phase 1/2
Fostroxacitabine Bralpamide None of these genes Phase 1/2
Gataparsen None of these genes Phase 1/2
Glutamine None of these genes Phase 1/2
Golvatinib None of these genes Phase 1/2
Hyaluronidase (Human Recombinant) None of these genes Phase 1/2
Ibcasertib None of these genes Phase 1/2
Ifinatamab Deruxtecan None of these genes Phase 1/2
Imifoplatin None of these genes Phase 1/2
Isatuximab None of these genes Phase 1/2
Ivuxolimab None of these genes Phase 1/2
Lancastotug None of these genes Phase 1/2
Linrodostat None of these genes Phase 1/2
Lucorafusp Alfa None of these genes Phase 1/2
Mapatumumab None of these genes Phase 1/2
Mb-07133 None of these genes Phase 1/2
Muzastotug None of these genes Phase 1/2
Napabucasin None of these genes Phase 1/2
Nelitolimod None of these genes Phase 1/2
Nogapendekin Alfa None of these genes Phase 1/2
Oprozomib None of these genes Phase 1/2
Oric-101 None of these genes Phase 1/2
Pidilizumab None of these genes Phase 1/2
Pr-104 None of these genes Phase 1/2
Pxs-5505 None of these genes Phase 1/2
Rocakinogene Sifuplasmid None of these genes Phase 1/2
Sacituzumab Govitecan None of these genes Phase 1/2
Sapanisertib None of these genes Phase 1/2
Sargramostim None of these genes Phase 1/2
Sirpiglenastat None of these genes Phase 1/2
Spartalizumab None of these genes Phase 1/2
Streptococcus Pneumoniae Polysaccharide Conjugated To Corynebacterium Diphtheriae Crm197 None of these genes Phase 1/2
Sugemalimab None of these genes Phase 1/2
Talimogene Laherparepvec None of these genes Phase 1/2
Tebotelimab None of these genes Phase 1/2
Tefinostat None of these genes Phase 1/2
Tegavivint None of these genes Phase 1/2
Tobemstomig None of these genes Phase 1/2
Tocilizumab None of these genes Phase 1/2
Tucidinostat None of these genes Phase 1/2
Utomilumab None of these genes Phase 1/2
Valemetostat None of these genes Phase 1/2
Valganciclovir None of these genes Phase 1/2
Varlitinib None of these genes Phase 1/2
Vebreltinib None of these genes Phase 1/2
Alectinib None of these genes Phase 1
Alextatug None of these genes Phase 1
.Alpha.-Pyrrolidinononanophenone None of these genes Phase 1
Artesunate None of these genes Phase 1
Azd-1480 None of these genes Phase 1
Azd-8055 None of these genes Phase 1
Biib-022 None of these genes Phase 1
Cenisertib None of these genes Phase 1
Charcoal, Activated None of these genes Phase 1
Cytidine None of these genes Phase 1
Danvatirsen None of these genes Phase 1
Deferoxamine None of these genes Phase 1
Denenicokin None of these genes Phase 1
Dusigitumab None of these genes Phase 1
Emibetuzumab None of these genes Phase 1
Enmd-2076 None of these genes Phase 1
Ery-974 None of these genes Phase 1
Evofosfamide None of these genes Phase 1
Exemestane None of these genes Phase 1
Ezabenlimab None of these genes Phase 1
Foretinib None of these genes Phase 1
Ganetespib None of these genes Phase 1
Guanosine None of these genes Phase 1
H3b-6527 None of these genes Phase 1
Hafnium Oxide None of these genes Phase 1
Interferon Alfacon-1 None of these genes Phase 1
Interleukin 15, Recombinant Non-Glycosylated None of these genes Phase 1
Ipafricept None of these genes Phase 1
Irx-2 None of these genes Phase 1
Itacitinib None of these genes Phase 1
Itraconazole None of these genes Phase 1
Lucitanib None of these genes Phase 1
Meclizine None of these genes Phase 1
Metenkefalin None of these genes Phase 1
Methionine None of these genes Phase 1
Modafinil None of these genes Phase 1
Nanrilkefusp Alfa None of these genes Phase 1
Onartuzumab None of these genes Phase 1
Ontuxizumab None of these genes Phase 1
Palverafusp Alfa None of these genes Phase 1
Panobinostat None of these genes Phase 1
Pazopanib None of these genes Phase 1
Pemetrexed None of these genes Phase 1
Pentamidine None of these genes Phase 1
Pimasertib None of these genes Phase 1
Pomalidomide None of these genes Phase 1
Porustobart None of these genes Phase 1
Recombinant Human Interleukin-15 None of these genes Phase 1
Retifanlimab None of these genes Phase 1
Rigosertib None of these genes Phase 1
Sar-439459 None of these genes Phase 1
Selinexor None of these genes Phase 1
Sf-1126 None of these genes Phase 1
Sitagliptin None of these genes Phase 1
Sumatriptan None of these genes Phase 1
Suratadenoturev None of these genes Phase 1
Tb-403 None of these genes Phase 1
Telisotuzumab Adizutecan None of these genes Phase 1
Tilarginine None of these genes Phase 1
Tovetumab None of these genes Phase 1
Tozinameran None of these genes Phase 1
Trametinib None of these genes Phase 1
Vactosertib None of these genes Phase 1
Vanucizumab None of these genes Phase 1
Vismodegib None of these genes Phase 1
Vorinostat None of these genes Phase 1
Vorolanib None of these genes Phase 1
Zotiraciclib None of these genes Phase 1
Ateganosine None of these genes Early phase 1
Boceprevir None of these genes Early phase 1
Tenofovir Alafenamide None of these genes Early phase 1
Cytochlor None of these genes Investigational new drug
Adefovir Dipivoxil None of these genes Unknown
Ademetionine None of these genes Unknown
Avatrombopag None of these genes Unknown
Balstilimab None of these genes Unknown
Carmofur None of these genes Unknown
Cholecalciferol None of these genes Unknown
Daclizumab None of these genes Unknown
Ferumoxytol None of these genes Unknown
Hepatitis B Immune Globulin None of these genes Unknown
Lamivudine None of these genes Unknown
Lidocaine None of these genes Unknown
Mebendazole None of these genes Unknown
Novaferon None of these genes Unknown
Perifosine None of these genes Unknown
Phytonadione None of these genes Unknown
Porfimer Sodium None of these genes Unknown
Propofol None of these genes Unknown
Regramostim None of these genes Unknown
Rencofilstat None of these genes Unknown
Retlirafusp Alfa None of these genes Unknown
Ropeginterferon Alfa-2b None of these genes Unknown
Sevoflurane None of these genes Unknown
Sym-021 None of these genes Unknown
Telbivudine None of these genes Unknown
Ulinastatin None of these genes Unknown
Velpatasvir None of these genes Unknown
Voxilaprevir None of these genes Unknown

The drug data is ChEMBL's, under CC BY-SA 3.0, and came through Open Targets release 26.09.